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The combination germline classification for this variant, ordinarily for your monogenic or Mendelian problem as during the ACMG/AMP rules, or for response to some drug. This worth is calculated by NCBI according to data from submitters. Examine our policies for calculating the aggregate classification.

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Stars depict the overview status, or the extent of critique supporting the submitted (SCV) file. This value is calculated by NCBI based upon knowledge from your submitter.

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ClinVar incorporates an entry for this variant (Variation ID: 574387). Variants that disrupt the consensus splice site are a comparatively popular reason behind aberrant splicing (PMID: 17576681, 9536098). Algorithms developed to predict the result of sequence variations on RNA splicing suggest that this variant could build or bolster a splice internet site. In summary, the out there evidence is at present insufficient to find out the position of this variant in disease. Hence, it has been labeled to be a Variant of Uncertain Significance. OK

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So this date may be unique in the date with the “most recent submission” described at the very best of the web page. Enable Adhere to NCBI

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